TFF
Tangential Flow Filtration.
Tangential flow filtration (TFF), is a commonly used process in bio-pharmaceutical and food industries. Tangential flow filtration (TFF) is a cost-effective way of removing impurities from large-volume samples.
Difference between Tangential Flow Filteration and Dead Flow Filteration:
- Flow is parallel to the filter membrane.
- Continuous filtration with fluid passing parallel to the filter.
- Less prone to clogging due to continuous flow.
- Facilitates continuous filtration.
- Creates a pressure differential that prevents contaminants from re-mixing with purified samples.
- Speed of results: Operates continuously and rapidly separates biomolecules.
- Multitasking: Can concentrate and filter samples on the same system.
- Ease of use: Relatively simpler pump, gauge, and tubing setup.
- Flexibility: Can process samples from small volumes to several thousands of liters.
- Flow is perpendicular to the filter membrane.
- Fluid is forced through the filter in a perpendicular manner.
- Prone to clogging as material is forced directly into the filter.
- Typically operates in batches.
- Does not inherently prevent contaminants from re-mixing.
- Simplicity: Simple setup with fluid being forced through the filter.